The concept of athleticism seems, at first glance, to be a minor component of Deleuze's analysis in Francis Bacon, appearing by name in the text only six times. In this article, I draw out the close link between athleticism and Deleuze's fundamental concept of intensity, arguing that this ostensibly minor term is in fact central to his account of the ‘clear and durable sensation’ produced by Bacon's painting. In tracing links between athleticism, Deleuze's aesthetic concept of ‘the fall’, and his (...) reliance on and critique of Kant's theory of intensive magnitudes, I show that athleticism in Francis Bacon names the form of intensity proper to painting. (shrink)

Edited collection on Wittgensteinian ethics. With contributions by Oskari Kuusela, Edward Harcourt, Anne-Marie Christensen, Sabina Lovibond, Alexander Miller, Benjamin De Mesel, Cora Diamond, Lars Hertzberg, Jeremy Johnson, Craig Taylor, Alice Crary, Lynette Reid.

Clinical research ethics consultation has emerged in the last 15 years as a service to those involved in the conduct of clinical research who face challenging issues for which more than one course of action may be justified. To respond to a growing field and need for opportunities to share knowledge and experience, the Clinical Research Ethics Consultation Collaborative, established in 2014, holds monthly webinars for its 90 members to present their most challenging cases to each other and engage in (...) substantive discussion. Every year, the group selects the four most interesting cases with accompanying commentaries for publication in the American Journal of Bioethics. This timely book brings together these cases and commentaries under a range of common themes for the first time, creating a permanent collection in book format that encourages and supports readers to gain a better understanding of the ethical challenges that they may face, and providing them with a convenient and reflective resource to reference in their own deliberations. Key Features- Comprehensive collection of cases and commentaries, chosen to reflect the range of issues faced by clinical researchers and oversight committees and illustrate the diversity of analysis that can arise. Supplemented by short introductions to each section. Focus on ethical rather than regulatory issues. Essential Reading for graduate students in bioethics and post-doctoral bioethics fellows, and useful for all participants in training grants that are funded by either NIH or NSF Presenting challenging cases to stimulate reflection, the book provides invaluable guidance to clinicians in training and in practice and to investigators, bioethics consultants, regulators, and oversight bodies. (shrink)

Acculturation is the process through which an individual's cultural behaviors and values change via contact with a majority or host culture. Although some individuals accomplish acculturation smoothly, most experience psychological stress during the acculturation process. When psychologists encounter individuals struggling to acculturate, they are mandated by ethical guidelines and principles to help through several steps: (a) recognize their own biases, beliefs, and attitudes that may influence their work with the acculturating individual; (b) develop competence to work with individuals whose cultural (...) beliefs and practices differ from their own; (c) counsel the acculturating individual using scientifically supported techniques; and (d) intervene without discrimination or disrespect. Two case studies are presented to illustrate how psychologists can ethically and effectively encourage mentally healthy acculturation. Keywords: acculturation, ethics, cultural differences. (shrink)

Contrary to what many philosophers believe, Calvinism neither makes the problem of evil worse nor is it obviously refuted by the presence of evil and suffering in our world. Or so most of the authors in this book claim. While Calvinism has enjoyed a resurgence in recent years amongst theologians and laypersons, many philosophers have yet to follow suit. The reason seems fairly clear: Calvinism, many think, cannot handle the problem of evil with the same kind of plausibility as other (...) more popular views of the nature of God and the nature of God's relationship with His creation. This book seeks to challenge that untested assumption. With clarity and rigor, this collection of essays seeks to fill a significant hole in the literature on the problem of evil. (shrink)

[Open access] In this book symposium the author takes up questions from phenomenology, hermeneutics, ethical theory, and intellectual history raised by a group of scholarly interlocutors from a range of backgrounds. In the course of engaging with these issues, he discusses, inter alia, McDowell’s realism, Jonathon Lear’s work on the end of a world, Michael Oakeshott’s view of selfhood, Heidegger’s conception of Jemeinigkeit, Uexküll’s notion of Umwelt, and Gadamer’s hermeneutic conception of truth.

BackgroundRobust ethics consultation services cannot be sustained by all hospitals; consultative service from a high-volume center via teleconferencing is an attractive alternative. This pilot study was conceived to explore the feasibility and understand the practical implications of offering such a service.MethodsHigh-definition videoconferencing was used to provide real-time interaction between the rounding clinicians and a remote clinical ethicist. Data collection included: (1) evaluation of the hardware and software required for teleconferencing, and (2) comparison of ethics trigger counts between the remote and (...) on-site ethicist during rounds.ResultsIssues with audio represented the majority of technical problems. Once technical difficulties were addressed, the onsite ethicist’s count of “triggers” was not statistically different from the count of the remote ethicist.ConclusionRemote clinical ethics rounding is feasible when the equipment is optimized. Remote ethicists can identify similar numbers of “triggers” for possible ethical issues when compared to on-site ethicist numbers. (shrink)

"In the first study of its kind, David W. Johnson's "Watsuji on Nature" reconstructs the astonishing philosophy of nature of Watsuji Tetsurō (1889-1960), situating it in relation both to his reception of the thought of Heidegger and to his renewal of core ontological positions in classical Confucian and Buddhist philosophy. Johnson shows that for Watsuji we have our being in the lived experience of nature, one in which nature and culture compose a tightly interwoven texture called "fūdo". (...) By fully unfolding Watsuji's novel and radical claim that this is a setting that is neither fully external to human subjectivity nor merely a product of it, this book also sets out what still remains unthought in this concept, as well as in the relational structure that underwrites it. Johnson argues that what remains unarticulated is nothing less than the recovery of a reenchanted conception of nature and an elucidation of the wide-ranging implications of a relational conception of the self for questions about the disclosive character of experience, the distinction between fact and value, and the possibility of a place-based ecological ethics. In an engagingly lucid and deft analysis, "Watsuji on Nature" radically expands our appreciation of twentieth-century Japanese philosophy and shows what it has to offer to a global philosophical conversation"--Provided by publisher. (shrink)

The rapid development of COVID-19 vaccines in 2020 involved an unprecedented clinical research initiative. The case here involves a Phase I clinical trial of “second-generation” COVID-19 vaccines d...

Volume 20, Issue 4, May 2020, Page 102-103.

Volume 20, Issue 4, May 2020, Page 111-113.

Volume 20, Issue 10, October 2020, Page 90-91.

For many rare diseases, the availability of effective interventions is limited or non-existent. In this context, clinical research evaluating emerging interventions may be the only potentially “the...

As part of the regulatory review process, both the Food and Drug Administration and Office for Human Research Protections (U.S. Department of Health and Human Services [HHS]...

Xenophon's Socratic Works demonstrates that Xenophon, a student of Socrates, military man, and man of letters, is an indispensable source for our understanding of the life and philosophy of Socrates. David M. Johnson restores Xenophon's most ambitious Socratic work, the Memorabilia, to its original literary context, enabling readers to experience it as Xenophon's original audience would have, rather than as a pale imitation of Platonic dialogue. He shows that the Memorabilia, together with Xenophon's Apology, provides us with our (...) best evidence for the trial of Socrates, and a comprehensive and convincing refutation of the historical charges against Socrates. Johnson's account of Socrates' moral psychology shows how Xenophon's emphasis on control of the passions can be reconciled with the intellectualism normally attributed to Socrates. Chapters on Xenophon's Symposium and Oeconomicus reveal how Xenophon used all the literary tools of Socratic dialogue to defend Socratic sexual morality and debate the merits and limits of conventional elite values. Throughout the book, Johnson argues that Xenophon's portrait of Socrates is rich and coherent, and largely compatible with the better-known portrait of Socrates in Plato. Xenophon aimed not to provide a rival portrait of Socrates, Johnson shows, but to supplement and clarify what others had said about Socrates. Xenophon's Socratic Works thus provides readers with a far firmer basis for reconstruction of the trial of Socrates, a key moment in the history of Athenian democracy, and for our understanding of Socrates' seminal impact on Greek philosophy. This volume introduces Xenophon's Socratic works to a wide range of readers, from undergraduate students encountering Socrates or ancient philosophy for the first time to scholars with interests in Socrates or ancient philosophy more broadly. It is also an important resource for readers interested in Socratic dialogue as a literary form, the trial of Socrates, Greek sexual morality, or Greek social history. (shrink)

Conviction Narrative Theory (CNT) is a theory of choice underradical uncertainty– situations where outcomes cannot be enumerated and probabilities cannot be assigned. Whereas most theories of choice assume that people rely on (potentially biased) probabilistic judgments, such theories cannot account for adaptive decision-making when probabilities cannot be assigned. CNT proposes that people usenarratives– structured representations of causal, temporal, analogical, and valence relationships – rather than probabilities, as the currency of thought that unifies our sense-making and decision-making faculties. According to CNT, (...) narratives arise from the interplay between individual cognition and the social environment, with reasoners adopting a narrative that feels “right” to explain the available data; using that narrative to imagine plausible futures; and affectively evaluating those imagined futures to make a choice. Evidence from many areas of the cognitive, behavioral, and social sciences supports this basic model, including lab experiments, interview studies, and econometric analyses. We identify 12 propositions to explain how the mental representations (narratives) interact with four inter-related processes (explanation, simulation, affective evaluation, and communication), examining the theoretical and empirical basis for each. We conclude by discussing how CNT can provide a common vocabulary for researchers studying everyday choices across areas of the decision sciences. (shrink)

The problem of defining ‘critical thinking’ needs a fresh approach. When one takes into consideration the sheer quantity of definitions and their obvious differences, an onlooker might be tempted to conclude that there is no inherent meaning to the term: that each author seems to consider that he or she is free to offer a definition that suits them. And, with a few exceptions, there has not been much discussion among proposers about the strength and weaknesses of the attempted definitions. (...) Therefore, the approach we will argue for here is a ‘meta-level approach’: proposers of new definitions of ‘critical thinking’ should begin by arguing that none of the current crop of definitions is viable. They should then state what kind of definition they will offer; then provide the definition and show that it satisfies the criteria stated. Our position is that new definitions should follow this meta-level approach, in addition to avoiding some common pitfalls. (shrink)

David Johnson seeks to overthrow one of the widely accepted tenets of Anglo-American philosophy—that of the success of the Humean case against the rational credibility of reports of miracles. In a manner unattempted in any other single work, he meticulously examines all the main variants of Humean reasoning on the topic of miracles: Hume's own argument and its reconstructions by John Stuart Mill, J. L. Mackie, Antony Flew, Jordan Howard Sobel, and others. Hume's view, set forth in his (...) essay "Of Miracles," has been widely thought to be correct. Johnson reviews Hume's thesis with clarity and elegance and considers the arguments of some of the most prominent defenders of Hume's case against miracles. According to Johnson, the Humean argument on this topic is entirely without merit, its purported cogency being simply a philosophical myth. (shrink)

This paper attempts to reconcile two ideas that seem fundamentally opposed to one another: the reality of the self and the doctrine of no-self. Buddhism offers a form of spiritual equanimity that turns on the denial of a self. Nonetheless, there seem to be good reasons to hold onto the reality of the self. The existence of a self enables us to account for praise and blame, the hopes for oneself that motivate actions, and attachments to the selves of others (...) in bonds of love and affection. I show how it may be possible to reconcile the reality of the self with a particular interpretation of the no-self doctrine by engaging with the work of thinkers from the phenomenological tradition such as Merleau-Ponty, Zahavi, Gallagher, and Petitmengin. (shrink)

Community Partnered Participatory Research is grounded in the ethical principle of respect for persons participating in the research enterprise. The critical importance of respect for person...

Disagreements about abortion are often assumed to reduce to disagreements about fetal personhood (and mindedness). If one believes a fetus is a person (or has a mind), then they are “pro-life.” If one believes a fetus is not a person (or is not minded), they are “pro-choice.” The issue, however, is much more complicated. Not only is it not dichotomous—most everyone believes that abortion is permissible in some circumstances (e.g. to save the mother’s life) and not others (e.g. at nine (...) months of a planned pregnancy)—but scholars on both sides of the issue (e.g. Don Marquis and Judith Thomson) have convincingly argued that fetal personhood (and mindedness) are irrelevant to the debate. To determine the extent to which they are right, this article will define “personhood,” its relationship to mindedness, and explore what science has revealed about the mind before exploring the relevance of both to questions of abortion’s morality and legality. In general, this article does not endorse a particular answer to these questions, but the article should enhance the reader’s ability to develop their own answers in a much more informed way. (shrink)

To Aaron Pacitti and Michael Cauvel–whose journal article, “Rent-Seeking Behavior and Economic Justice: A Classroom Exercise” broadly argues that “understanding the [complexities] of rent-seeking behavior helps fill the gap between economics and politics”–the varieties of rent are wide and, therefore, can only be described in their category-specific positions. I will discuss three of these categories in more detail below, but for now, I propose that a useful working grasp of economic rent involves “the amount paid to the owner of a (...) factor of production over the cost that is to be necessarily incurred on utilizing such elements in the production process.” In math terms, ‘economic rent’ equals the agreed-upon-amount paid by the consumer (when that amount far exceeds the market value of the product) minus the cost spent by the producer to make the product (when that cost is far below the typical amount to produce the product). Originally, the concept of economic rent concerned land ownership and the production of natural goods. Two major economists, Adam Smith and David Ricardo, offered insights into the general makeup and logic of what they called, the rent of land and simply rent, respectively. (shrink)

There has recently been a flurry of activity in the philosophy of language on how to best account for the unique features of epithets. One of these features is that epithets can be appropriated (that is, the offense-grounding potential of a term can be removed). We argue that attempts to appropriate an epithet fundamentally involve a violation of language-governing rules. We suggest that the other conditions that make something an attempt at appropriation are the same conditions that characterize acts of (...) civil disobedience. Accounting for attempts at appropriation is thus both a linguistic and socio-political endeavor. We demonstrate how these two facets of attempts at appropriation also help us understand the communicative features of civil disobedience. (shrink)

In C. S. Lewis’s Christian Apologetics: Pro and Con, I took the con in a debate with Victor Reppert about the soundness of Lewis’s famous “argument from reason.” Reppert then extended his argument in an article for Philosophia Christi; this article is my reply. I show that Reppert’s argument fails for three reasons. (1) It “loads the die” by falsely assuming that naturalism, by definition, can't include mental causation "on the basic level." (I provide multiple examples of naturalist theories of (...) mind that do exactly that). (2) Physical processes can reliably produce true beliefs. And (3) reasoning isn’t necessarily mental. (shrink)

The understanding of decision-making systems has come together in recent years to form a unified theory of decision-making in the mammalian brain as arising from multiple, interacting systems (a planning system, a habit system, and a situation-recognition system). This unified decision-making system has multiple potential access points through which it can be driven to make maladaptive choices, particularly choices that entail seeking of certain drugs or behaviors. We identify 10 key vulnerabilities in the system: (1) moving away from homeostasis, (2) (...) changing allostatic set points, (3) euphorigenic signals, (4) overvaluation in the planning system, (5) incorrect search of situation-action-outcome relationships, (6) misclassification of situations, (7) overvaluation in the habit system, (8) a mismatch in the balance of the two decision systems, (9) over-fast discounting processes, and (10) changed learning rates. These vulnerabilities provide a taxonomy of potential problems with decision-making systems. Although each vulnerability can drive an agent to return to the addictive choice, each vulnerability also implies a characteristic symptomology. Different drugs, different behaviors, and different individuals are likely to access different vulnerabilities. This has implications for an individual's susceptibility to addiction and the transition to addiction, for the potential for relapse, and for the potential for treatment. (shrink)

Quality-space theory (QST) explains the nature of the mental qualities distinctive of perceptual states by appeal to their role in perceiving. QST is typically described in terms of the mental qualities that pertain to color. Here we apply QST to the olfactory modalities. Olfaction is in various respects more complex than vision, and so provides a useful test case for QST. To determine whether QST can deal with the challenges olfaction presents, we show how a quality space (QS) could be (...) constructed relying on olfactory perceptible properties and the olfactory mental qualities then defined by appeal to that QS of olfactory perceptible properties. We also consider how to delimit the olfactory QS from other modalities. We further apply QST to the role that experience plays in refining our olfactory discriminative abilities and the occurrence of olfactory mental qualities in non-conscious olfactory states. QST is shown to be fully applicable to and useful for understanding the complex domain of olfaction. (shrink)

Despite the importance of linguistic disclosure for philosophical hermeneutics there has been a conspicuous lack of attention to the question of how linguistic disclosure actually works. I examine the mechanics of disclosure by drawing on Gadamer’s philosophical hermeneutics as well as Ricoeur’s concept of translation and his theory of metaphor. My claim is that the background horizon of the unsaid that differs between languages enables each to disclose different things. This situation underscores the importance of engaging in East-West comparative philosophy, (...) of philosophizing across what Ricoeur calls the radical “fold” (pli) in what can be thought and experienced. (shrink)

An infinite number of elastically colliding balls is considered in a classical, and then in a relativistic setting. Energy and momentum are not necessarily conserved globally, even though each collision does separately conserve them. This result holds in particular when the total mass of all the balls is finite, and even when the spatial extent and temporal duration of the process are also finite. Further, the process is shown to be indeterministic: there is an arbitrary parameter in the general solution (...) that corresponds to the injection of an arbitrary amount of energy (classically), or energy-momentum (relativistically), into the system at the point of accumulation of the locations of the balls. Specific examples are given that illustrate these counter-intuitive results, including one in which all the balls move with the same velocity after every collision has taken place. (shrink)

An interruption. Rethinking the first three chapters of this book, I have come to suspect that, not unlike Iris Murdoch and Emmanuel Levinas, the way I imagine ‘ethics’ floats on an idea that any ethical substantive position or ethical theory is always shaped through our existential condition and our embodied encounter with others. To Murdoch, existence is the disposition for our responses to the ways in which we perceive reality, and yet, although these responses are always part of who we (...) are, they are not always part of what we do, and so, we set ourselves ethical tasks when we desire to act ethically. As scholar Bridget Clarke argues, “to attend to something [for Murdoch] is to approach it with a just and loving eye, and therewith to perceive it in its unbounded particularity and complexity, and so, as it truly is.” Or as I argue, to attend to the other ‘justly and lovingly’, Murdoch would instruct, is not merely to accurately collect details about the other and then arrive at an approximation of its being, but also to apprehend the other as ‘distinctly singular’ and ‘distinctly foreign’ from oneself–which at once forgoes any assimilation of the other into oneself, incidentally. The recognition of the other as ‘one who embodies human otherness and dignity’ becomes the condition for and coherent way of imagining and accessing moral reality. Moreover, for Diane Davis, this “being-for-the-other names a pre-originary obligation to respond to the other [and] it is in this response that both the self and the other emerge as existents” whose ethical projects are each challenged by the markedly different and infinitely other being. This obligation, Levinas might also say, is an ‘authority’ that is experienced like the effect of the other upon me, so that I am subsequently motivated to enact ethical task-making. I am not, therefore, “pulling everything other into the same, the known, the comprehended,” nor am I looking to any normative theories as authoritative templates from which I act ethically. And so, unlike Husserl, I am not “joining the philosophical tradition in its fundamental disrespect for all things other,” but instead, by dispositioning myself between these theories in responsible Levinasian fashion, I will be tracking them in response to their confronting me, and not as normative theories that are applicable to real and lived experiences. (shrink)

Genomic sequencing is becoming more common both in clinical practice and as a routine aspect of much research. Over the last 15 years there has been ongoing discussion about the implications of gen...

This chapter focuses on one of the common fallacies in Western philosophy, “confirmation bias”. Confirmation bias is the human tendency only to look for evidence that confirms what one wants to believe or what one already thinks is true. Usually people are not too keen to look for evidence against what they want to believe is true. The human propensity for self‐delusion is strong. When one is confronted with sufficient evidence against some belief that one holds, what one should do (...) is reject that belief ‐ at least if one is concerned with truth. When we surround ourselves with people and views that already agree with our own, we can draw erroneous conclusions. Confirmation bias greatly hinders one's ability to find the truth. Confirmation bias and evidence denial is why we start “seeing something everywhere” once you learn about it. The more scrutiny a belief can withstand, the more likely it is that it's true. (shrink)

Currently, there is consensus that community engagement and partnerships are essential to inclusive patient-centered clinical research. Yet there is variation about what it means to do this well an...

In a recent book and article, James Sterba has argued that there is no free will defense. It is the purpose of this article to show that, in the most technical sense, he is wrong. There is a version of the free will defense that can solve what Sterba (rightly) takes to be the most interesting and severe version of the logical problem of moral evil. However, I will also argue that, in effect (or, we might say, in practice), Sterba (...) is correct. The only working version of the free will defense requires embracing a view that entails consequences theists traditionally have not and cannot accept. Consequently, the one and only free will solution is not viable. Unless some other solution can be found (Sterba argues there is none), the logical problem of evil, as Sterba understands it, either commits one to atheism, or a version of theism that practically all theists would regard as a heresy. (shrink)

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill‐suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in an out‐of‐equilibrium regime that allows the quantification of PT in virtually any biological context. We propose a simple mathematical and conceptual framework applicable to a broad range of available data, such as RNA sequencing coupled with pulsed‐SILAC datasets. We apply our framework to (...) a published dataset and show that stimulation of mouse dendritic cells with LPS leads to a proteome‐wide change in PT. This is the first quantification of PT out‐of‐equilibrium, paving the way for the analysis of biological systems in other contexts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: I would like to begin by thanking the Journal of Japanese Philosophy for making space in these pages for a review of my monograph Watsuji on Nature: Japanese Philosophy in the Wake of Heidegger. Although book reviews do not usually receive a reply from the author—much less one as lengthy as the article that follows—one seemed necessary in this instance because my ideas, unfortunately, have been seriously mis-represented (...) here. Moreover, the number and kinds of misreadings, mistakes, misunderstandings, and omissions are so extensive that even a brief attempt to address the main points at issue is no small task. But the primary problem is that the reviewer contends that I say the opposite of what I actually maintain with regard to some of the central claims of the book. These mistaken assertions are primarily the consequence of a failure to understand crucial philosophical concepts (especially metaphysical nondualism, being-in-the-world, intentionality, and disclosure). But they also stem from a series of errors ranging from the exclusion of some of the fundamental ideas and arguments of the book to the misreading of pivotal claims and the mistranslation of the Japanese-language primary sources.I begin with a single but telling example that is characteristic of the way the reviewer repeatedly portrays me as saying the opposite of what I actually say. Droz states that “For Johnson, while human beings taken collectively as a whole have the capacity to transcend the fūdo, individual human beings apparently do not” (Droz, 133). But what I actually say is that Watsuji “has not shown that this same capacity belongs to the individual human being” (Johnson, 191). I then give a series of examples of individual transcendence: “the forms of transcendence that are evident in, for example, the complex identities of immigrants, of those who have lived in multiple countries, of those who live in multiple milieus at the same time [...] of those who develop a very different character from their compatriots even as they live together in the same place” (Johnson, 191). [End Page 167] I go on to point out that “we also need a subtler account, on a much smaller scale, of the ways the self is both constituted by and is also able to transcend its fūdo. In what follows we will give an indication of some of the issues involved” (Johnson, 191). I then proceed to give such an overview, concluding with the point that “the strong identification with one aspect of one’s milieu rather than another shows that the self is much more than the simple expression of its fūdo. This form of transcendence, I suggest, can be studied with profit as an instance of what Watsuji calls the individual dimension of human beings” (Johnson, 192).Misrepresentations of this sort abound. The most serious instance of this kind concerns one of the central theses of this study. At the beginning of her review, the author purports to recount two criteria that I propose “to clarify what the philosophical concept of fūdo entails” (Droz, 129). But in fact, I list four criteria under two distinct categories. First, in order to determine the scope and boundaries of a fūdo, I propose the following two criteria:1. certain regions as articulated wholes found in nature itself, which is what Watsuji attempts to articulate with his taxonomy of basic types of fūdo (Johnson, 34).2. a relational whole of disclosure, self-interpretation, and natural locale (Johnson, 34).But the reviewer takes note of (1) and passes over (2) in silence—this omission is significant and, as we will see shortly, it leads her into later difficulties. Droz instead moves directly to a second topic, namely, what I intend by the term nature, which is a concept found in both of these criteria. Here I follow Mill in thinking that we need some way to distinguish between nature and nonnature if nature is not simply to be equated with everything. I therefore propose two criteria that we might use to distinguish nature from artifice within a fūdo: A. nature as all-encompassing space and place B. the sheerly given self-unfolding of things . (shrink)

Understanding the mechanisms of early embryonic patterning and the timely allocation of specific cells to embryonic regions and fates as well as their development into tissues and organs, is a fundamental problem in Developmental Biology. The classical explanation for this process had been built around the notion of positional information. Accordingly the programmed appearance of sources of Morphogens at localized positions within a field of cells directs their differentiation. Recently, the development of organs and tissues from unpatterned and initially identical (...) stem cells (adult and embryonic) has challenged the need for positional information and even the integrity of the embryo, for pattern formation. Here we review the emerging area of organoid biology from the perspective of Developmental Biology. We argue that the events underlying the development of these systems are not purely linked to “self‐organization,” as often suggested, but rather to a process of genetically encoded self‐assembly where genetic programs encode and control the emergence of biological structures. (shrink)

The orphaned son of an Anglican clergyman, David Hartley (1705–57) was originally destined for holy orders. Declining to subscribe to the Thirty-Nine Articles, he turned to medicine and science yet remained a religious believer. This, his most significant work, provides a rigorous analysis of human nature, blending philosophy, psychology and theology. First published in two volumes in 1749, Observations on Man is notable for being based on the doctrine of the association of ideas. It greatly influenced scientists, theologians, social (...) reformers and poets: Samuel Taylor Coleridge, who named his eldest son after Hartley, had his portrait painted while holding a copy. In Volume 1, Hartley utilises Newtonian science in his observations, presenting his theory of 'vibrations'. Volume 2 is particularly concerned with human morality and the duty and expectations of mankind. Hartley is keen to show that scientific observation is not necessarily in conflict with religious conviction. (shrink)

Christian apologists, like Willian Lane Craig and Stephen T. Davis, argue that belief in Jesus’ resurrection is reasonable because it provides the best explanation of the available evidence. In this article, I refute that thesis. To do so, I lay out how the logic of inference to the best explanation (IBE) operates, including what good explanations must be and do by definition, and then apply IBE to the issue at hand. Multiple explanations—including (what I will call) The Resurrection Hypothesis, The (...) Lie Hypothesis, The Coma Hypothesis, The Imposter Hypothesis, and The Legend Hypothesis—will be considered. While I will not attempt to rank them all from worst to best, what I will reveal is how and why The Legend Hypothesis is unquestionably the best explanation, and The Resurrection Hypothesis is undeniably the worst. Consequently, not only is Craig and Davis’ conclusion mistaken, but belief in the literal resurrection of Jesus is irrational. In presenting this argument, I do not take myself to be breaking new ground; Robert Cavin and Carlos Colombetti have already presented a Bayesian refutation of Craig and Davis’ arguments. But I do take myself to be presenting an argument that the average person (and philosopher) can follow. It is my goal for the average person (and philosopher) to be able to clearly understand how and why the hypothesis “God supernaturally raised Jesus from the dead” fails utterly as an explanation of the evidence that Christian apologist cite for Jesus’ resurrection. (shrink)

PET studies in domains like vision and attention have been successful because the experiments are the product of highly articulated theories. In contrast, the results of PET studies investigating language processing are difficult to interpret. We suggest that this difficulty is due to the more tentative connection of these experiments with the insights of psycholinguistics and linguistic theory.

Over the last two decades republican thought has attracted a growing interest from political, moral and legal scholars. These contemporary theoretical syntheses of ‘neo-republican’ thought have been closely related to intellectual history and the idea of recovering an overshadowed tradition of political thought. In this vein, a classical set of historical moments and places and specific political practices within those contexts appear to be the main source of what republicanism meant – and what it could mean today.